Publications

Inhibition of Neuron Restrictive Silencing Factor (REST/NRSF) Chromatin Binding Attenuates Epileptogenesis. Hall AM, Kamei N, Shao M, Mun HS, Chen K, Chen Y, Baram TZ. eNeuro. 2024 Apr 19. PMID: 38641413.

Paroxysmal dystonia results from the loss of RIM4 in Purkinje cells. Kim H, Melliti N, Breithausen E, Michel K, Colomer SF, Poguzhelskaya E, Nemcova P, Ewell L, Blaess S, Becker A, Pitsch J, Dietrich D, Schoch S. Brain. 2024 Mar 13. PMID: 38478593.

Selective block of human Kv1.1 channels and an epilepsy-associated gain-of-function mutation by AETX-K peptide. Zhao R, Qasim A, Sophanpanichkul P, Dai H, Nayak M, Sher I, Chill J, Goldstein SAN. FASEB J. 2024 Jan. PMID: 38102952

Early deficits in dentate circuit and behavioral pattern separation after concussive brain injury. Corrubia L, Huang A, Nguyen S, Shiflett MW, Jones MV, Ewell LA, Santhakumar V. Exp Neurol. 2023 Dec. PMID: 37858696.

Medicinal plant rosemary relaxes blood vessels by activating vascular smooth muscle KCNQ channels. Manville RW, Baldwin SN, Eriksen EØ, Jepps TA, Abbott GW. FASEB J. 2023 Sep. PMID: 37535015.

Vector-mediated PTEN deletion in the adult dentate gyrus initiates new growth of granule cell bodies and dendrites and expansion of mossy fiber terminal fields that continues for months. Yonan JM, Steward O. Neurobiology of Disease. 2023 Aug;184:106190. PMID: 37290578.

The plant-derived alkaloid aloperine prevents ischemia/reperfusion injury-induced sudden cardiac death. Hu Z, Li J, Liu Q, Manville RW, Abbott GW. FASEB J. 2023 Jul. PMID: 37249366.

A positively tuned voltage indicator for extended electrical recordings in the brain. Evans SW, Shi DQ, Chavarha M, Plitt MH, Taxidis J, Madruga B, Fan JL, Hwang FJ, van Keulen SC, Suomivuori CM, Pang MM, Su S, Lee S, Hao YA, Zhang G, Jiang D, Pradhan L, Roth RH, Liu Y, Dorian CC, Reese AL, Negrean A, Losonczy A, Makinson CD, Wang S, Clandinin TR, Dror RO, Ding JB, Ji N, Golshani P, Giocomo LM, Bi GQ, Lin MZ. Nature Methods. Jul;20(7):1104-1113. PMID: 37429962.

Ancient medicinal plant rosemary contains a highly efficacious and isoform-selective KCNQ potassium channel opener. Manville RW, Hogenkamp D, Abbott GW. Commun Biol. 2023 Jun. PMID: 37322081.

Native American ataxia medicines rescue ataxia-linked mutant potassium channel activity via binding to the voltage sensing domain. Manville RW, Alfredo Freites J, Sidlow R, Tobias DJ, Abbott GW. Nat Commun. 2023 Jun. PMID: 37280215.

Behavioral and neuro-functional consequences of eliminating the KCNQ3 GABA binding site in mice. Chen KJ, Yoshimura R, Edmundo CA, Truong TM, Civelli O, Alachkar A, Abbott GW. Front Mol Neurosci. 2023 May. PMID: 37305551.

Conditional deletion of neurexin-2 alters neuronal network activity in hippocampal circuitries and leads to spontaneous seizures
Haile MT, Khoja S, de Carvalho G, Hunt RF, Chen LY. Translational Psychiatry. 2023 Mar 20;13(1):97. PMID: 36941261.

Vascular topology and blood flow are acutely impacted by experimental febrile status epilepticus. Salehi A, Salari S, Jullienne A, Daglian J, Chen K, Baram TZ, Obenaus A. J Cereb Blood Flow Metab. 2023 Jan;43(1):84-98. doi: 10.1177/0271678X221117625. Epub 2022 Aug 1. PMID: 35912523

Targeting aberrant dendritic integration to treat cognitive comorbidities of epilepsy. Masala N, Pofahl M, Haubrich AN, Islam KUS, Nikbakht N, Pasdarnavab M, Bohmbach K, Araki K, Kamali F, Henneberger C, Golcuk K, Ewell LA, Blaess S, Kelly T, Beck H. Brain. 2022 Nov 30:awac455. doi: 10.1093/brain/awac455. Online ahead of print. PMID: 36448426

Editorial: Neuroinflammation in acquired epilepsy. Jiang J, Santhakumar V, Zhu X. Front Cell Dev Biol. 2022 Nov 7;10:1074537. doi: 10.3389/fcell.2022.1074537. eCollection 2022. PMID: 36420137

Low-Cost Platform for Multianimal Chronic Local Field Potential Video Monitoring with Graphical User Interface (GUI) for Seizure Detection and Behavioral Scoring. Tarcsay G, Boublil BL, Ewell LA. eNeuro. 2022 Oct 12;9(5):ENEURO.0283-22.2022. doi: 10.1523/ENEURO.0283-22.2022. Print 2022 Sep-Oct. PMID: 36192155

EEG biomarkers for the diagnosis and treatment of infantile spasms. Romero Milà B, Remakanthakurup Sindhu K, Mytinger JR, Shrey DW, Lopour BA. Front Neurol. 2022 Jul 28;13:960454. doi: 10.3389/fneur.2022.960454. eCollection 2022. PMID: 35968272

Brain-wide reconstruction of inhibitory circuits after traumatic brain injury. Frankowski JC, Tierno A, Pavani S, Cao Q, Lyon DC, Hunt RF. Nat Commun. 2022 Jun 14;13(1):3417. doi: 10.1038/s41467-022-31072-2. PMID: 35701434 

Long-Term Effects of Moderate Concussive Brain Injury During Adolescence on Synaptic and Tonic GABA Currents in Dentate Granule Cells and Semilunar Granule Cells. Gupta A, Dovek L, Proddutur A, Elgammal FS, Santhakumar V. Front Neurosci. 2022 Mar 14;16:800733. doi: 10.3389/fnins.2022.800733. eCollection 2022. PMID: 35360164

Oxytocin normalizes altered circuit connectivity for social rescue of the Cntnap2 knockout mouse. Choe KY, Bethlehem RAI, Safrin M, Dong H, Salman E, Li Y, Grinevich V, Golshani P, DeNardo LA, Peñagarikano O, Harris NG, Geschwind DH. Neuron. 2022 Mar 2;110(5):795-808.e6. doi: 10.1016/j.neuron.2021.11.031. Epub 2021 Dec 20. PMID: 34932941

Beyond rates: time-varying dynamics of high frequency oscillations as a biomarker of the seizure onset zone. Nunez MD, Charupanit K, Sen-Gupta I, Lopour BA, Lin JJ. J Neural Eng. 2022 Feb 22;19(1):10.1088/1741-2552/ac520f. doi: 10.1088/1741-2552/ac520f. PMID: 35120337

Differential Activity-Dependent Increase in Synaptic Inhibition and Parvalbumin Interneuron Recruitment in Dentate Granule Cells and Semilunar Granule Cells. Afrasiabi M, Gupta A, Xu H, Swietek B, Santhakumar V. J Neurosci. 2022 Feb 9;42(6):1090-1103. doi: 10.1523/JNEUROSCI.1360-21.2021. Epub 2022 Jan 3. PMID: 34980636 

The Double-Edged Sword: Are Endocannabinoids Doing More Harm than Good in Epilepsy? Boublil BL, Ewell LA. Epilepsy Curr. 2021 Dec 8;22(2):139-140. doi: 10.1177/15357597211062412. eCollection 2022 Mar-Apr. PMID: 35444504

Activation of SGK1.1 Upregulates the M-current in the Presence of Epilepsy Mutations. Martin-Batista E, Manville RW, Rivero-Pérez B, Bartolomé-Martín D, Alvarez de la Rosa D, Abbott GW, Giraldez T. Front Mol Neurosci. 2021 Nov 26;14:798261. doi: 10.3389/fnmol.2021.798261. eCollection 2021. PMID: 34899186

Reduced hippocampal inhibition and enhanced autism-epilepsy comorbidity in mice lacking neuropilin 2. Eisenberg C, Subramanian D, Afrasiabi M, Ziobro P, DeLucia J, Hirschberg PR, Shiflett MW, Santhakumar V, Tran TS. Transl Psychiatry. 2021 Oct 18;11(1):537. doi: 10.1038/s41398-021-01655-6. PMID: 34663783

Identification of neural oscillations and epileptiform changes in human brain organoids. Samarasinghe RA, Miranda OA, Buth JE, Mitchell S, Ferando I, Watanabe M, Allison TF, Kurdian A, Fotion NN, Gandal MJ, Golshani P, Plath K, Lowry WE, Parent JM, Mody I, Novitch BG. Nat Neurosci. 2021 Oct;24(10):1488-1500. doi: 10.1038/s41593-021-00906-5. Epub 2021 Aug 23. PMID: 34426698 

Computational characteristics of interictal EEG as objective markers of epileptic spasms. Smith RJ, Hu DK, Shrey DW, Rajaraman R, Hussain SA, Lopour BA. Epilepsy Res. 2021 Oct;176:106704. doi: 10.1016/j.eplepsyres.2021.106704. Epub 2021 Jun 25. PMID: 34218209

Seizure Phenotype and Underlying Cellular Defects in Drosophila Knock-In Models of DS (R1648C) and GEFS+ (R1648H) SCN1A Epilepsy. Roemmich AJ, Vu T, Lukacsovich T, Hawkins C, Schutte SS, O’Dowd DK. eNeuro. 2021 Sep 20;8(5):ENEURO.0002-21.2021. doi: 10.1523/ENEURO.0002-21.2021. Print 2021 Sep-Oct. PMID: 34475263

Abnormal sleep physiology in children with 15q11.2-13.1 duplication (Dup15q) syndrome. Saravanapandian V, Nadkarni D, Hsu SH, Hussain SA, Maski K, Golshani P, Colwell CS, Balasubramanian S, Dixon A, Geschwind DH, Jeste SS. Mol Autism. 2021 Aug 3;12(1):54. doi: 10.1186/s13229-021-00460-8. PMID: 34344470

A Behavioral Screen for Heat-Induced Seizures in Mouse Models of Epilepsy. Das A, Smith MA, O’Dowd DK. J Vis Exp. 2021 Jul 12;(173). doi: 10.3791/62846. PMID: 34309607

Increased excitatory to inhibitory synaptic ratio in parietal cortex samples from individuals with Alzheimer’s disease. Lauterborn JC, Scaduto P, Cox CD, Schulmann A, Lynch G, Gall CM, Keene CD, Limon A. Nat Commun. 2021 May 10;12(1):2603. doi: 10.1038/s41467-021-22742-8. PMID: 33972518 

Interneuron Dysfunction in a New Mouse Model of SCN1A GEFS. Das A, Zhu B, Xie Y, Zeng L, Pham AT, Neumann JC, Safrina O, Benavides DR, MacGregor GR, Schutte SS, Hunt RF, O’Dowd DK. eNeuro. 2021 Apr 12;8(2):ENEURO.0394-20.2021. doi: 10.1523/ENEURO.0394-20.2021. Print 2021 Mar-Apr. PMID: 33658306

Augmented seizure susceptibility and hippocampal epileptogenesis in a translational mouse model of febrile status epilepticus. Chen KD, Hall AM, Garcia-Curran MM, Sanchez GA, Daglian J, Luo R, Baram TZ. Epilepsia. 2021 Mar;62(3):647-658. doi: 10.1111/epi.16814. Epub 2021 Jan 21. PMID: 33475157

A TrkB agonist and ampakine rescue synaptic plasticity and multiple forms of memory in a mouse model of intellectual disability. Seese RR, Le AA, Wang K, Cox CD, Lynch G, Gall CM. Neurobiol Dis. 2020 Feb;134:104604. doi: 10.1016/j.nbd.2019.104604. Epub 2019 Sep 5. PMID: 31494285

Automated detection of ripple oscillations in long-term scalp EEG from patients with infantile spasms. McCrimmon CM, Riba A, Garner C, Maser AL, Phillips DJ, Steenari M, Shrey DW, Lopour BA. J Neural Eng. 2021 Feb 22;18(1). doi: 10.1088/1741-2552/abcc7e. PMID: 33217752

KCNQ Potassium Channels as Targets of Botanical Folk Medicines. Redford KE, Abbott GW. Annu Rev Pharmacol Toxicol. 2022 Jan 6;62:447-464. doi: 10.1146/annurev-pharmtox-052120-104249. Epub 2021 Sep 13.PMID: 34516289

Amplitude of high frequency oscillations as a biomarker of the seizure onset zone. Charupanit K, Sen-Gupta I, Lin JJ, Lopour BA. Clin Neurophysiol. 2020 Nov;131(11):2542-2550. doi: 10.1016/j.clinph.2020.07.021. Epub 2020 Aug 25. PMID: 32927209

From Plugging the Dam to Fueling the Firing: Platelets Breach the Barrier to Seize the Brain. Nguyen S, Santhakumar V. Epilepsy Curr. 2020 Aug 26;20(5):300-302. doi: 10.1177/1535759720948117. eCollection 2020 Sep-Oct. PMID: 34025245

Distinct cellular mediators drive the Janus faces of toll-like receptor 4 regulation of network excitability which impacts working memory performance after brain injury. Korgaonkar AA, Nguyen S, Li Y, Sekhar D, Subramanian D, Guevarra J, Pang KCH, Santhakumar V. Brain Behav Immun. 2020 Aug;88:381-395. doi: 10.1016/j.bbi.2020.03.035. Epub 2020 Apr 4. PMID: 32259563

Trends in the use of automated algorithms for the detection of high-frequency oscillations associated with human epilepsy. Remakanthakurup Sindhu K, Staba R, Lopour BA. Epilepsia. 2020 Aug;61(8):1553-1569. doi: 10.1111/epi.16622. Epub 2020 Jul 30. PMID: 32729943

KCNQs: Ligand- and Voltage-Gated Potassium Channels. Abbott GW. Front Physiol. 2020 Jun 23;11:583. doi: 10.3389/fphys.2020.00583. eCollection 2020.PMID: 32655402 

Current ex Vivo and in Vitro Approaches to Uncovering Mechanisms of Neurological Dysfunction after Traumatic Brain Injury. Hamilton KA, Santhakumar V. Curr Opin Biomed Eng. 2020 Jun;14:18-24. doi: 10.1016/j.cobme.2020.05.001. Epub 2020 May 11. PMID: 32548365

Detection of anomalous high-frequency events in human intracranial EEG. Charupanit K, Sen-Gupta I, Lin JJ, Lopour BA. Epilepsia Open. 2020 May 20;5(2):263-273. doi: 10.1002/epi4.12397. eCollection 2020 Jun. PMID: 32524052

Effect of interictal epileptiform discharges on EEG-based functional connectivity networks. Hu DK, Mower A, Shrey DW, Lopour BA. Clin Neurophysiol. 2020 May;131(5):1087-1098. doi: 10.1016/j.clinph.2020.02.014. Epub 2020 Mar 4. PMID: 32199397

M-Current Suppression, Seizures and Lipid Metabolism: A Potential Link Between Neuronal Kv7 Channel Regulation and Dietary Therapies for Epilepsy. Hoshi N. Front Physiol. 2020 May 25;11:513. doi: 10.3389/fphys.2020.00513. eCollection 2020. PMID: 32523549 

Toll-like Receptor 4 Signaling in Neurons Enhances Calcium-Permeable α-Amino-3-Hydroxy-5-Methyl-4-Isoxazolepropionic Acid Receptor Currents and Drives Post-Traumatic Epileptogenesis. Korgaonkar AA, Li Y, Sekhar D, Subramanian D, Guevarra J, Swietek B, Pallottie A, Singh S, Kella K, Elkabes S, Santhakumar V. Ann Neurol. 2020 Apr;87(4):497-515. doi: 10.1002/ana.25698. Epub 2020 Feb 24. PMID: 32031699 

Breakdown of spatial coding and interneuron synchronization in epileptic mice. Shuman T, Aharoni D, Cai DJ, Lee CR, Chavlis S, Page-Harley L, Vetere LM, Feng Y, Yang CY, Mollinedo-Gajate I, Chen L, Pennington ZT, Taxidis J, Flores SE, Cheng K, Javaherian M, Kaba CC, Rao N, La-Vu M, Pandi I, Shtrahman M, Bakhurin KI, Masmanidis SC, Khakh BS, Poirazi P, Silva AJ, Golshani P. Nat Neurosci. 2020 Feb;23(2):229-238. doi: 10.1038/s41593-019-0559-0. Epub 2020 Jan 6. PMID: 31907437 

Comparisons of dual isogenic human iPSC pairs identify functional alterations directly caused by an epilepsy associated SCN1A mutation. Xie Y, Ng NN, Safrina OS, Ramos CM, Ess KC, Schwartz PH, Smith MA, O’Dowd DK. Neurobiol Dis. 2020 Feb;134:104627. doi: 10.1016/j.nbd.2019.104627. Epub 2019 Nov 28. PMID: 31786370

M-Channel Activation Contributes to the Anticonvulsant Action of the Ketone Body β-Hydroxybutyrate. Manville RW, Papanikolaou M, Abbott GW. J Pharmacol Exp Ther. 2020 Feb;372(2):148-156. doi: 10.1124/jpet.119.263350. Epub 2019 Nov 22. PMID: 31757819

Born to Be Wild: A Case for Targeting Ectopic Adult Born Granule Cells for Seizure Control. Corrubia L, Santhakumar V. Epilepsy Curr. 2020 Jan-Feb;20(1):57-60. doi: 10.1177/1535759719891438. Epub 2019 Dec 3.PMID: 32037879

Default network and frontoparietal control network theta connectivity supports internal attention. Kam JWY, Lin JJ, Solbakk AK, Endestad T, Larsson PG, Knight RT. Nat Hum Behav. 2019 Dec;3(12):1263-1270. doi: 10.1038/s41562-019-0717-0. Epub 2019 Sep 2. PMID: 31477910

Dexamethasone Attenuates Hyperexcitability Provoked by Experimental Febrile Status Epilepticus. Garcia-Curran MM, Hall AM, Patterson KP, Shao M, Eltom N, Chen K, Dubé CM, Baram TZ. eNeuro. 2019 Nov 15;6(6):ENEURO.0430-19.2019. doi: 10.1523/ENEURO.0430-19.2019. Print 2019 Nov/Dec. PMID: 31685676

Converging early responses to brain injury pave the road to epileptogenesis. Neuberger EJ, Gupta A, Subramanian D, Korgaonkar AA, Santhakumar V. J Neurosci Res. 2019 Nov;97(11):1335-1344. doi: 10.1002/jnr.24202. Epub 2017 Nov 29. PMID: 29193309 

Transplanted interneurons improve memory precision after traumatic brain injury. Zhu B, Eom J, Hunt RF. Nat Commun. 2019 Nov 14;10(1):5156. doi: 10.1038/s41467-019-13170-w. PMID: 31727894

Cilantro leaf harbors a potent potassium channel-activating anticonvulsant. Manville RW, Abbott GW. FASEB J. 2019 Oct;33(10):11349-11363. doi: 10.1096/fj.201900485R. Epub 2019 Jul 16. PMID: 31311306

Goldilocks Zone of Ictal Onset: Partially Recovered Synapses Provide the Kindling to Fuel Ictal Activity. Subramanian D, Santhakumar V. Epilepsy Curr. 2019 Sep;19(5):330-332. doi: 10.1177/1535759719869670. Epub 2019 Aug 13. PMID: 31409150 

Epilepsy Therapy Goes Viral. Lim BC, Hunt RF. Epilepsy Curr. 2019 Sep;19(5):328-329. doi: 10.1177/1535759719870506. Epub 2019 Aug 28. PMID: 31462070

WONOEP appraisal: Network concept from an imaging perspective. Wykes RC, Khoo HM, Caciagli L, Blumenfeld H, Golshani P, Kapur J, Stern JM, Bernasconi A, Dedeurwaerdere S, Bernasconi N. Epilepsia. 2019 Jul;60(7):1293-1305. doi: 10.1111/epi.16067. Epub 2019 Jun 9. PMID: 31179547 

Ripple-related firing of identified deep CA1 pyramidal cells in chronic temporal lobe epilepsy in mice. Marchionni I, Oberoi M, Soltesz I, Alexander A. Epilepsia Open. 2019 Mar 4;4(2):254-263. doi: 10.1002/epi4.12310. eCollection 2019 Jun. PMID: 31168492 

Editorial for the special issue on language and epilepsy. Bonilha L, Small SS, Lin JJ. Brain Lang. 2019 Jun;193:1-3. doi: 10.1016/j.bandl.2019.03.002. Epub 2019 Mar 28. PMID: 30929763

Reduced Prefrontal Synaptic Connectivity and Disturbed Oscillatory Population Dynamics in the CNTNAP2 Model of Autism. Lazaro MT, Taxidis J, Shuman T, Bachmutsky I, Ikrar T, Santos R, Marcello GM, Mylavarapu A, Chandra S, Foreman A, Goli R, Tran D, Sharma N, Azhdam M, Dong H, Choe KY, Peñagarikano O, Masmanidis SC, Rácz B, Xu X, Geschwind DH, Golshani P. Cell Rep. 2019 May 28;27(9):2567-2578.e6. doi: 10.1016/j.celrep.2019.05.006. PMID: 31141683 

Chd2 Is Necessary for Neural Circuit Development and Long-Term Memory. Kim YJ, Khoshkhoo S, Frankowski JC, Zhu B, Abbasi S, Lee S, Wu YE, Hunt RF. Neuron. 2018 Dec 5;100(5):1180-1193.e6. doi: 10.1016/j.neuron.2018.09.049. Epub 2018 Oct 18. PMID: 30344048

Attenuating M-current suppression in vivo by a mutant Kcnq2 gene knock-in reduces seizure burden and prevents status epilepticus-induced neuronal death and epileptogenesis. Greene DL, Kosenko A, Hoshi N. Epilepsia. 2018 Oct;59(10):1908-1918. doi: 10.1111/epi.14541. Epub 2018 Aug 26. PMID: 30146722

Strength and stability of EEG functional connectivity predict treatment response in infants with epileptic spasms. Shrey DW, Kim McManus O, Rajaraman R, Ombao H, Hussain SA, Lopour BA. Clin Neurophysiol. 2018 Oct;129(10):2137-2148. doi: 10.1016/j.clinph.2018.07.017. Epub 2018 Aug 4. PMID: 30114662

Selective vulnerability of hippocampal interneurons to graded traumatic brain injury. Frankowski JC, Kim YJ, Hunt RF. Neurobiol Dis. 2019 Sep;129:208-216. doi: 10.1016/j.nbd.2018.07.022. Epub 2018 Jul 19. PMID: 30031783

Treating a novel plasticity defect rescues episodic memory in Fragile X model mice. Wang W, Cox BM, Jia Y, Le AA, Cox CD, Jung KM, Hou B, Piomelli D, Gall CM, Lynch G. Mol Psychiatry. 2018 Aug;23(8):1798-1806. doi: 10.1038/mp.2017.221. Epub 2017 Nov 14. PMID: 29133950

Automated Detection of High Frequency Oscillations in Human Scalp Electroencephalogram. Charupanit K, Nunez MD, Bernardo D, Bebin M, Krueger DA, Northrup H, Sahin M, Wu JY, Lopour BA. Annu Int Conf IEEE Eng Med Biol Soc. 2018 Jul;2018:3116-3119. doi: 10.1109/EMBC.2018.8513033. PMID: 30441054

Quantitative Characteristics of Hypsarrhythmia in Infantile Spasms. Smith RJ, Shrey DW, Hussain SA, Lopour BA. Annu Int Conf IEEE Eng Med Biol Soc. 2018 Jul;2018:538-541. doi: 10.1109/EMBC.2018.8512348. PMID: 30440453

Using electrocorticogram baseline seizure frequency to assess the efficacy of responsive neurostimulation. Young MG, Vadera S, Lin JJ, Mnatsakanyan L. Epilepsy Behav. 2018 Aug;85:7-9. doi: 10.1016/j.yebeh.2018.05.008. Epub 2018 Jun 8. PMID: 29890343

Irritable No More: Activating Mossy Cells for the Treatment of Epilepsy. Kim YJ, Hunt RF. Epilepsy Curr. 2018 Jul-Aug;18(4):251-252. doi: 10.5698/1535-7597.18.4.251.PMID: 30254523

Neuronal PTEN deletion in adult cortical neurons triggers progressive growth of cell bodies, dendrites, and axons. Gallent EA, Steward O. Exp Neurol. 2018 May;303:12-28. doi: 10.1016/j.expneurol.2018.01.005. Epub 2018 Jan 11.PMID: 29337147

Direct neurotransmitter activation of voltage-gated potassium channels. Manville RW, Papanikolaou M, Abbott GW. Nat Commun. 2018 May 10;9(1):1847. doi: 10.1038/s41467-018-04266-w.PMID: 29748663

Reefer to the Rescue: The Dope on Cannabidiol as a Multi-Symptom Panacea for Dravet Syndrome. Gupta A, Santhakumar V. Epilepsy Curr. 2018 Mar-Apr;18(2):118-120. doi: 10.5698/1535-7597.18.2.118. PMID: 29643753